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Voriconazole: What it treats, how to take it, and what to watch for
Voriconazole is a prescription antifungal used for serious infections like invasive aspergillosis, some Candida infections, and other hard-to-treat fungal diseases. Doctors pick it when milder drugs won’t work or when infections are deep in the lungs, brain, or bloodstream.
How it works is simple: voriconazole stops fungi from making a component of their cell membrane, which hurts their growth. Because it’s powerful, doctors monitor you closely while you’re on it.
Typical dosing and practical tips
Common adult dosing starts with a loading dose, then a maintenance dose. For most adults that means a loading dose (IV or oral) followed by 200 mg by mouth every 12 hours as maintenance. IV dosing uses weight-based amounts (often 6 mg/kg loading, then 4 mg/kg every 12 hours). Doses change for children, very small or large adults, and people with liver problems.
If you have liver disease, your doctor will lower the maintenance dose. The IV form contains a sugar-based vehicle (SBECD) that can accumulate in severe kidney failure, so doctors may prefer oral dosing if your kidney function is poor.
Therapeutic drug monitoring (TDM) is common with voriconazole. Trough levels help keep the drug effective but not toxic. Many clinicians aim for a trough around 1–5 mcg/mL, but your care team will set the exact target based on your situation.
Side effects, interactions, and safety
Expect some common side effects: visual changes (blurred vision, light sensitivity), nausea, headache, and skin rash. More serious risks include liver injury, QT prolongation (a heart rhythm effect), and severe skin reactions. Long-term use has been linked to photosensitivity and, rarely, skin cancers—so protect your skin from strong sunlight.
Voriconazole interacts with many drugs. It affects CYP2C19, CYP2C9, and CYP3A4 enzymes, so it can raise or lower levels of medicines like warfarin, some statins, certain anti-seizure drugs, and immunosuppressants (tacrolimus, sirolimus). Tell your prescriber about every medicine and supplement you take.
Avoid using voriconazole during pregnancy unless the benefits clearly outweigh the risks. It can harm a developing baby in animal studies. Use effective contraception while on treatment if pregnancy is possible.
Want to buy voriconazole online? Only use legitimate pharmacies that require a prescription. Look for clear contact info, a licensed pharmacist, secure payment, and verified reviews. Beware of very cheap offers, no-prescription sellers, or sites that hide their address. When in doubt, ask your healthcare provider for a trusted pharmacy recommendation.
If you’re prescribed voriconazole, follow your doctor’s instructions, get recommended blood tests, watch for vision or skin changes, and report any worrying symptoms fast. This drug can be lifesaving, but it needs careful handling.