PUVA Therapy: What It Is and How It Helps Skin Conditions

When you hear PUVA therapy, a treatment that blends UVA light exposure with a photosensitizing drug called psoralen. Also known as Psoralen + UVA, it is used to calm stubborn skin disorders that don’t respond to topical creams alone.

How PUVA Therapy Works

PUVA therapy combines two core components: ultraviolet A (UVA) radiation and a medication that makes skin cells more receptive to light. The drug—usually 8‑Methoxypsoralen—gets taken orally or applied topically, then the patient steps into a controlled light chamber. This pairing slows down the rapid growth of skin cells, reduces inflammation, and can even restore pigment in areas affected by certain conditions.

One of the most common targets for PUVA is psoriasis, an autoimmune disease that causes thick, scaly patches on the skin. By moderating the immune response, PUVA can clear plaques that resist steroids or biologics. Another condition that often sees improvement is vitiligo, a disorder where pigment‑producing cells die, leading to white patches. The light‑activated drug helps repigment these areas, especially when treatment starts early.

PUVA belongs to the broader family of phototherapy, medical treatments that use specific light wavelengths to manage skin and autoimmune diseases. While narrowband UVB is another popular option, PUVA reaches deeper layers of skin, making it valuable for thick plaques or extensive disease. However, because it involves a drug, doctors monitor dosage carefully to limit side effects like nausea or increased sun sensitivity.

Patients considering PUVA should expect a series of sessions—typically two to three times a week—until the skin shows noticeable improvement. Treatment length varies; some achieve results after a few weeks, others continue for months. Doctors also advise protective eyewear during exposure to prevent eye damage, and regular skin checks to catch any early signs of long‑term risks.

Below you’ll find a curated set of articles that dive deeper into PUVA’s practical aspects, compare it with other therapies, and share real‑world tips for managing side effects. Whether you’re new to phototherapy or looking to fine‑tune an existing regimen, these resources will give you a clearer picture of what to expect and how to get the most out of PUVA therapy.